michaelisaiahlove at gmail dot com *
* for software questions, do not email, instead use the Bioconductor support site
News and upcoming talks
- Sean McCabe’s second paper is preprinted: “ACTOR: a latent Dirichlet model to compare expressed isoform proportions to a reference panel” doi: 10.1101/856401
- Joshua Zitovsky’s first paper is up on F1000Research: “Fast effect size shrinkage software for beta-binomial models of allelic imbalance” doi: 10.12688/f1000research.20916.1
- Sarah Reifeis’s first paper is preprinted: “Assessing exposure effects on gene expression” doi: 10.1101/806554
- Arjun Bhattacharya’s first paper is preprinted: “A framework for transcriptome-wide association studies in breast cancer in diverse study populations” doi: 10.1101/769570
The Love Lab uses statistical models to infer biologically meaningful patterns in high-dimensional datasets, and develops open-source statistical software for the Bioconductor Project. At UNC-Chapel Hill, we often collaborate with groups in the Genetics Department and the Lineberger Comprehensive Cancer Center, studying how genetic variants relevant to diseases are associated with changes in molecular and cellular phenotypes.
- We collaborate with the Patro lab in the development of computational and statistical methods for quantification of RNA transcript abundance, including the software packages Salmon and tximeta.
- We collaborate with the Stein lab in the study of genetic risk for neuropsychiatric disorders, leveraging data from molecular assays of chromatin accessibility and the transcriptome in neural progenitor cell lines to macroscale phenotypes such as gross human brain structure measured with MRI.
- We collaborate with the Troester lab and the Carolina Breast Cancer Study, investigating the intersection between gene expression profiles of breast tumors and genetic risk for breast cancer, with a focus on racial disparities in patient outcomes.
- We develop, support, and maintain the DESeq2 package for statistical analysis of RNA-seq and other sequencing experiments, and associated packages and workflows for analyzing genomics data. See the Software tab for more details.
PI - Background
From 2013-2016, I was a Postdoctoral Fellow in the group of Rafael Irizarry in the Biostatistics and Computational Biology Department at the Dana-Farber Cancer Institute and the Harvard TH Chan School of Public Health. I completed a PhD in Computational Biology and Scientific Computing (2013) in the Vingron Department at the Max Planck Institute for Molecular Genetics in Berlin and the Mathematics and Informatics Department of the Freie Universität, Berlin. I completed a Statistics M.S. (2010) and Mathematics B.S. (2005) at Stanford University.
Past news items
- August 2019 - Anqi Zhu’s second paper published in Nucleic Acids Research: doi: 10.1093/nar/gkz622, which describes the Swish method in the fishpond package.
- July 2019 - Sean McCabe’s first paper published in Briefings in Bioinformatics: doi: 10.1093/bib/bbz070, 2019 Author Manuscript
- February 2019 - Anqi Zhu’s second paper posted to bioRxiv: Nonparametric expression analysis using inferential replicate counts
- October 2018 - Swimming downstream… DTU workflow published on F1000Research is now indexed.
- July 2018 - Sean McCabe sent off his first preprint: MOVIE: Multi-Omics VIsualization of Estimated contributions, which describes the movie software.
- June 2018 - A new differential transcript usage workflow from the Love Lab is published in F1000Research: Swimming downstream
- April 2018 - Anqi Zhu sent off the first preprint from the lab: Heavy-tailed prior distributions for sequence count data, which describes the apeglm software.
- December 2017 - Anqi Zhu and Michael Love featured in a Nature article talking about the Bioconductor Project for genomic data analysis.