Love Lab

PI: Michael I. Love
Assistant Professor
Department of Biostatistics
Department of Genetics
Member of Lineberger Comprehensive Cancer Center
University of North Carolina-Chapel Hill

@mikelove — Google Scholar — Biostatistics Dept profile

michaelisaiahlove at gmail dot com *

* for software questions, do not email, instead use the Bioconductor support site

Upcoming talks

  • February 7, 2019 - Epigenetics and Stem Cell Biology seminar series at NIEHS
  • March 7, 2019 - Department of Biostatistics and Bioinformatics, Emory University
  • March 27, 2019 @ 8:30am - ENAR, Teaching Data Science through Case Studies, invited session
  • May 31, 2019 @ 3:30pm - ASA Symposium on Data Science & Statistics, abstract
  • July 29, 2019 @ 2pm - JSM, Making an Impact in Statistics Education through Innovation and Outreach

Research

The Love Lab uses statistical models to infer biologically meaningful patterns in high-dimensional datasets, and develops open-source statistical software for the Bioconductor Project. At UNC-Chapel Hill, we collaborate with groups in the Genetics Department and the Lineberger Comprehensive Cancer Center, studying how genetic variants relevant to diseases are associated with changes in molecular and cellular phenotypes.

  • We collaborate with the Patro lab in the development of computational and statistical methods for quantification of RNA transcript abundance, including the software packages Salmon and tximeta.
  • We collaborate with the Stein lab in the study of genetic risk for neuropsychiatric disorders, leveraging data from molecular assays of chromatin accessibility and the transcriptome in neural progenitor cell lines to macroscale phenotypes such as gross human brain structure measured with MRI.
  • We develop, support, and maintain the DESeq2 package for statistical analysis of RNA-seq and other sequencing experiments, and associated packages and workflows for analyzing genomics data. See the Software tab for more details.

PI - Background

From 2013-2016, I was a Postdoctoral Fellow in the group of Rafael Irizarry in the Biostatistics and Computational Biology Department at the Dana-Farber Cancer Institute and the Harvard TH Chan School of Public Health. I completed a PhD in Computational Biology and Scientific Computing (2013) in the Vingron Department at the Max Planck Institute for Molecular Genetics in Berlin and the Mathematics and Informatics Department of the Freie Universität, Berlin. I completed a Statistics M.S. (2010) and Mathematics B.S. (2005) at Stanford University.

Past news items

  • November 2018 - Michael Love gave a talk at the Duke Epigenetics and Epigenomics Program Seminar Series.
  • October 2018 - Michael Love gave a talk at Duke University: Computational Biology & Bioinformatics Series
  • October 2018 - Swimming downstream… DTU workflow published on F1000Research is now indexed.
  • September 2018 - Michael Love gave a talk at Brown SPH Statistics Seminar Series
  • July 2018 - Sean McCabe sent off his first preprint: MOVIE: Multi-Omics VIsualization of Estimated contributions, which describes the movie software.
  • June 2018 - A new differential transcript usage workflow from the Love Lab is published in F1000Research: Swimming downstream
  • April 2018 - Anqi Zhu sent off the first preprint from the lab: Heavy-tailed prior distributions for sequence count data, which describes the apeglm software.
  • May 2018 - Michael Love gave a talk at NC State’s Bioinformatics Research Center Seminar Series.
  • February 2018 - Michael Love gave a talk at UVA’s Center for Public Health Genomics: Fragment-level bias modeling for RNA-seq Data Analysis (link to Google Slides).
  • December 2017 - Anqi Zhu and Michael Love featured in a Nature article talking about the Bioconductor Project for genomic data analysis.
  • December 2016 - Michael Love gave a talk at UMD’s Computational Biology, Bioinformatics & Genomics seminar series.
  • October 2016 - Michael Love gave a talk at the Triangle Statistical Genetics Meeting, SAS Campus, Cary.